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111 OCT gives greater resolution (10 µm) and has been utilised thoroughly for plaque characterization.112–114 Serial intravascular imaging reports have confirmed the development of atherosclerotic plaque takes place above quite a few many years, and morphological options like cap thinning, plaque burden115 and microcalcifications together with shear tension—rather then luminal narrowing—decide the possibility of plaque rupture.109 Therein lies the problem of detection, as these susceptible plaques typically continue being clinically silent due to their non-obstructive character, right until unexpected plaque rupture and subsequent localized thrombosis brings about an acute coronary syndrome.
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The situation presented over highlights the uncertainties in each day acute cardiovascular care—while the concepts from the 4th UDMI are pathophysiologically sound, They may be complicated to determine operationally. What is necessary are evolutions in scientific observe that should help people to be put inside the pathological framework described within the 4th UDMI.